Review
Copyright ©The Author(s) 2016.
World J Gastroenterol. Jan 28, 2016; 22(4): 1650-1663
Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1650
Table 4 Considerations with direct acting antivirals in renal dysfunction
DAA agent or combinationIssues in renal dysfunction
SofosbuvirContraindication in GFR < 30 mL/min due to insufficient safety data[127]
SimeprevirNo dose adjustment[75]
LedipasvirLimited data; no theoretical concerns[127]
PTV/r + OMB + DSVSafe and effective and no dose adjustment in ESRD[100]
DaclatasvirNo dose adjustment[78]
Elbasvir/GrazoprevirSafe and effective and no dose adjustment in ESRD[101]