Hepatitis C in non-hepatic solid organ transplant candidates and recipients: A new horizon

doi:10.3748/wjg.v22.i4.1650

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Jan 28, 2016 (publication date) through Jul 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2016; 22(4): 1650-1663
Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1650

Table 4 Considerations with direct acting antivirals in renal dysfunction

DAA agent or combination	Issues in renal dysfunction
Sofosbuvir	Contraindication in GFR < 30 mL/min due to insufficient safety data[127]
Simeprevir	No dose adjustment[75]
Ledipasvir	Limited data; no theoretical concerns[127]
PTV/r + OMB + DSV	Safe and effective and no dose adjustment in ESRD[100]
Daclatasvir	No dose adjustment[78]
Elbasvir/Grazoprevir	Safe and effective and no dose adjustment in ESRD[101]

DAA: Direct acting antiviral; ESRD: End stage renal disease; GFR: Glomerular filtration rate; PTV: Paritaprevir; r: Ritonavir; OMB: Ombitasvir; DSV: Dasabuvir.

Citation: Belga S, Doucette KE. Hepatitis C in non-hepatic solid organ transplant candidates and recipients: A new horizon. World J Gastroenterol 2016; 22(4): 1650-1663
URL: https://www.wjgnet.com/1007-9327/full/v22/i4/1650.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i4.1650