Liver pathology of hepatitis C, beyond grading and staging of the disease

Table 1 Liver histology in hepatitis C infection

Histological features of acute hepatitis C
Cholestatic injury
	Bile duct injury (Poulsen Christofferson lesion)
	Bile duct injury (Poulsen Christofferson lesion)
	Cholangiolar proliferation (mild)
Hepatocytic injury
	Lobular necroinflammation with disarray
	Steatosis
	Sinusoidal inflammation
Histological features of chronic hepatitis C
Portal changes
	Portal lymphoid aggregates/reactive lymphoid follicles
	Interface hepatitis
	Bile duct damage
	Isolated clusters of hepatocytes in portal tracts
	Phlebitis
Lobular injury
	Necroinflammation
	Steatosis
	Multinucleation and nuclear pleomorphism
	Sinusoidal cell hyperplasia
	Microgranulomas
Fibrosis
Preneoplastic changes
	Large cell change
	Small cell change
	Iron free foci