Metastasis-associated long noncoding RNAs in gastrointestinal cancer: Implications for novel biomarkers and therapeutic targets

doi:10.3748/wjg.v22.i39.8735

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2016; 22(39): 8735-8749
Published online Oct 21, 2016. doi: 10.3748/wjg.v22.i39.8735

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Figure 4 Regulating function of HOTAIR in gastrointestinal cancer. In nucleus, HOTAIR recruits PRC2 complex and represses pri-miR-34a transcription epigenetically. By inducing histone H3K27 methylation in WIF-1’s promoter region, HOTAIR decreases WIF-1 expression. In cytoplasm, HOTAIR serves as “sponges” for miR-331-3p and miR-152, leading to the increase of target genes HER2 and HLA-G. PRC2: Polycomb repressive complex2.

Citation: Zhang FF, Luo YH, Wang H, Zhao L. Metastasis-associated long noncoding RNAs in gastrointestinal cancer: Implications for novel biomarkers and therapeutic targets. World J Gastroenterol 2016; 22(39): 8735-8749
URL: https://www.wjgnet.com/1007-9327/full/v22/i39/8735.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i39.8735