Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome

Figure 3 Classic pathway of bile acid biosynthesis in the liver. A: Conversion of 7α-hydroxycholesterol to 5β-cholestan-3α, 7α-diol - a precursor of chenodeoxycholyl-CoA - and of 7α-hydroxycholesterol to 5β-cholestan-3α, 7α,12α-triol - a precursor of cholyl-CoA. B: Conversion of 5β-cholestan-3α, 7α, 12α-triol to cholyl-CoA. Note that the conversion of 5β-cholestan-3α,7α-diol to chenodeoxycholyl-CoA biosynthesis takes place in the same manner and it is catalyzed by the same liver enzymes (not shown).