Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma

Table 2 Univariate and Multivariate analyses of factors associated with recurrence and survival

Factors	Time to recurrence				Overall survival
	Univariate	Multivariate			Univariate	Multivariate
	P value	Hazard ratio	95%CI	P value	P value	Hazard ratio	95%CI	P value
Age: ≥ 60 yr vs < 60 yr	0.240			NA	0.523			NA
Gender: female vs male	0.760			NA	0.111			NA
Indx of α-SMA: ≥ 12 vs < 12	0.751			NS	0.423			NS
Indx of CD163: ≥ 26 vs < 26	< 0.001	4.517	1.879-10.857	0.001	< 0.001	1.086	1.039-1.135	< 0.001
M-CSF density: ≥ 36 vs < 36	< 0.001	4.826	2.045-11.389	< 0.001	0.037			NS
Indx of CD31: ≥ 20 vs < 20	0.002			NS	0.020			NS
AFP: ≥ 100 vs < 100	0.232			NA	0.785			NA
AFP-L3%: ≥ 10 vs < 10	0.827			NA	0.900			NA
PIVKA-II: ≥ 100 vs < 100	0.841			NA	0.325			NA
Tumor size: ≥ 2 cm vs < 2 cm	0.185			NA	0.847			NA
Tumor number: multiple vs single	0.447			NA	0.038			NS
Tumor differentiation:	0.379			NA	0.745			NA
well vs mod. vs poor
Fibrosis score: 1, 2, 3 vs 4	0.755			NA	0.015			0.002
TNM stage: I vs II vs IIIa	0.020			NS	0.173			NA

Tables are shown univariate and multivariate analysis of prognostic markers associated with the disease-free and the overall survival.