Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program

Table 6 Diagnostic values of predicting the four esophageal lesions based on the positive expression of the three biomarkers combined at the cut off value of 10%-25%¹ (%)

Group	Sensitivity	95%CI	+PV	95%CI
ESCC	58.2	49.4-66.7	89.7	81.3-95.1
HGD	25.5	14.3-39.6	59.1	36.4-79.3
LGD	11.2	7.6-15.8	75.7	58.8-88.2
BCH	6.5	2.2-14.5	35.7	12.9-64.8

¹If the expression of any one of the three biomarkers was positive, the combined expression was counted as positive; if there was an overlap in expression, the score of the strongest expression was taken as the score of the combination. The specificity was 88.8% for the normal control group, with a 95%CI of 79.7%-94.7%. ESCC: Esophageal squamous cell cancer; HGD: High-grade dysplasia; LGD: Low-grade dysplasia; BCH: Basal cell hyperplasia.