Combination of three-gene immunohistochemical panel and magnetic resonance imaging-detected extramural vascular invasion to assess prognosis in non-advanced rectal cancer patients

Table 2 Multivariate Cox regression analysis of factors predicting survival time of patients without regional lymph node and distant metastasis

Variable	HR	95%CI	P value
Sex (male vs female)	1.312	0.784-2.159	0.354
Pathologic T stage (T3-4 vs T1-2)	1.226	0.817-2.657	0.012
Lymphovascular invasion (yes vs no)	1.413	0.716-1.971	0.241
Perineural invasion (yes vs no)	1.539	0.992-2.321	0.114
EMVI (positive vs negative)	3.071	2.784-5.754	< 0.01
c-MYC expression (low vs strong)	1.138	1.003-2.421	0.032
PCNA expression (strong vs low)	2.582	1.748-4.373	0.003
TIMP1 expression (low vs strong)	2.643	1.869-5.821	0.021
IHC panel (2-3 markers high vs 0-1 marker high)	2.110	1.631-2.556	< 0.01

EMVI: Extramural vascular invasion; IHC: Immunohistochemistry.