Characterisation of colonic dysplasia-like epithelial atypia in murine colitis

Figure 6 Localisation of β-catenin in Winnie distal colonic mucosa. A: Representative image of Winnie distal colon of the six animals without DSS exposure immunostained for β-catenin. B-catenin in the colonic epithelium is primarily associated with the epithelial cell membrane; B: Immunostained dysplastic distal colonic mucosa from a Winnie mouse exposed to three cycles of DSS (representative of n = 11). B-catenin localised to the cell membrane of epithelial cells without any nuclear accumulation. Scale bar is equivalent to 100 μm.