Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis

Figure 3 Effects of rhubarb extract and 5-fluorouracil on disease activity scores on days 6 to 8 of the experimental period. Rats received a daily water, HDR or LDR gavage for an 8-d trial period and an intraperitoneal injection of 5-FU or saline on day 5. Disease activity scores were assigned on Days 6 to 8 based on overall condition, weight loss, stool consistency and rectal bleeding. ^bP < 0.01, ^eP < 0.001 vs water + saline; ^cP < 0.05 vs water + 5-FU. LDR: Low-dose RE; HDR: High-dose RE; RE: Rhubarb extract.