Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales

Table 7 Comparison of outcomes between good and poor responders

Ref.	Year	Good response defn.	Poor response defn.	LR %		P < 0.05	DR %		P < 0.05	DFS %		P < 0.05	OS %		P < 0.05	DSS		P < 0.05	Conclusion
				GR	PR		GR	PR		GR	PR		GR	PR		GR	PR
Pucciarelli et al[28]	2004	TRG 1 and 2 and 3	TRG 4 and 5							Better in GR		No	Better in GR		No				Good responders have better, non-statistically significant outcomes for DFS and OS
Suárez et al[31]	2008	TRG 1 and 2	TRG 3 and 4 and 5	0	3.4	NC	0	14.3	NC	Better in GR		Yes				Better in GR		No	Good responders have better, statistically significant DFS but have better, non significant LR, DR and DSS
Bujko et al[18]	2010	TRG 1	TRG 3	9	26	No	34	47	No	67	47	No							Good responders have better, non-statistically significant outcomes for LR, DR and DFS
Avallone et al[13]	2011	TRG 2 and 3	TRG 4 and 5							Prob > 90%	Prob 56%	Yes							Good responders have better, statistically significant DFS
Shin et al[30]	2011	TRG 1 and 2 and 3	TRG 4 and 5							74.1	72.6	No							Good responders have better, non-statistically significant outcomes for DFS
Lim et al[26]	2012	TRG 3 and 4	TRG 1 and 2	1.3	9.5	Yes	11.6	27.2	Yes	86.7	63.6	Yes	88.2	71.3	Yes				Good responders have better, statistically significant outcomes for LR, DR, DFS and OS
Roy et al[29]	2012	TRG 1 and 2 and 3	TRG 4 and 5							86.1	60.3	Yes	92.2	87.3	No				Good responders have better, statistically significant DFS but have better, non significant OS
Roy et al[29]	2012	TRG 2 and 3 and 4	TRG 0 and 1							91.7	68.9	No	89.2	92.6	No				Good responders had better, non-statistically significant outcomes for DFS. Good responders had poorer, non-statistically significant outcomes for OS
Vallböhmer et al[32]	2012	TRG 3	TRG 1										Better in GR		No				Good responders have better, non-statistically significant outcomes for OS
Vallböhmer et al[32]	2012	TRG 2a and 2b	TRG 1										Better in GR		No				Good responders have better, non-statistically significant outcomes for OS
Vallböhmer et al[32]	2012	TRG 3 and 4	TRG 1 and 2										Better in GR		No				There was no statistically significant difference for OS between good and poor responders
Fokas et al[14]	2014	TRG 2 and 3	TRG 0 and 1	8	3.6	No	29.3	39.6	Yes	73.6	63	Yes							Good responders have better, statistically significant outcomes for DR and DFS. Good responders had poorer, non-statistically significant outcomes for LR
Santos et al[16]	2014	TRG 1 and 2	TRG 3 and 4 and 5	1.4	4.3	NC	8.6	20.3	NC	81.7	61.7	Yes	79.4	60.7	Yes				Good responders have better, statistically significant outcomes for DFS and OS
Santos et al[16]	2014	TRG 3 and 4	TRG 0 and 1 and 2	1.8	3.5	NC	11.1	16.4	NC	78.4	68.1	No	77.4	69.1	No				Good responders have better, non-statistically significant outcomes for DFS and OS
Hav et al[15]	2015	TRG 3 and 4	TRG 0 and 1 and 2							Better in GR		No							Good responders have better, non-statistically significant outcomes for DFS

Where data is not given the overall result is stated. LR: Local recurrence; DR: Distant recurrence; GR: Good responders; PR: Poor responders; NC: No statistical comparison made.