Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales

Table 6 Study definitions of good response according to histopathological tumour regression grade scales

Ref.	Year	TRG scale used (original disease application)	Are the scales reported accurately?	Good response definition	Total (n)	Good responders (n)	Average F/up in months	LR (%) 5 yr	DR (%) 5 yr	DFS (%)	OS (%)
Gambacorta et al[21]	2004	Mandard (oesophagus)	Yes	TRG 1 and 2	54	24	25
Pucciarelli et al[28]	2004	Mandard (oesophagus)	Yes	TRG 1 and 2 and 3	104	52	42			DNE	DNE
Horisberger et al[24]	2008	Japanese Society for Cancer of the Colon and Rectum (rectal)	Yes	TRG 2 and 3	59	33
Suárez et al[31]	2008	Mandard (oesophagus)	Yes	TRG 1 and 2	119	36	33	0	0	DNE
Bujko et al[18]	2010	Glynne Jones/Bujko (rectal)	Yes	TRG 1	131	40	48	9	34	Yr. 4: 67
Avallone et al[13]	2011	Mandard (oesophagus)	Yes	TRG 2 and 3	63	20	60			Yr. 5: Prob free of recurrence > 90%
Shin et al[30]	2011	Mandard (oesophagus)	Yes	TRG 1 and 2 and 3	102	52	40.3			Yr. 3: 74.1
Huebner et al[25]	2012	Dworak (rectal)	Yes	TRG 2 and 3 and 4	237	176
Lim et al[26]	2012	Dworak (rectal)	Yes	TRG 3 and 4	581	224	61	1.3	11.6	Yr. 5: 86.7	Yr. 5: 88.2
Roy et al[29]	2012	Dworak (rectal)	Yes	TRG 2 and 3 and 4	75	33				Yr. 2: 91.7	Yr. 2: 89.2
Roy et al[29]	2012	Mandard (oesophagus)	Yes	TRG 1 and 2 and 3	75	51				Yr. 2: 86.1	Yr. 2: 92.2
Vallböhmer et al[32]	2012	Japanese Society for Cancer of the Colon and Rectum (rectal)	Yes	TRG 3	85	23					DNE
Vallböhmer et al[32]	2012	Junker Miller (lung)	Yes	TRG 2aand2b	85	65					DNE
Vallböhmer et al[32]	2012	Cologne (oesophageal)	Yes	TRG 3 and 4	85	26					DNE
Winkler et al[33]	2012	Dworak (rectal)	No	TRG 3	33	6
Elezkurtaj et al[20]	2013	Dworak (rectal)	Yes	TRG 3 and 4	102	34
Fokas et al[14]	2014	Dworak (rectal)	Yes	TRG 2 and 3	386	256	132	Yr. 10: 8.0	Yr. 10: 29.3	Yr. 10: 73.6%
Santos et al[16]	2014	Dworak (rectal)	Yes	TRG 3 and 4	144	54	56	1.8	11.1	Yr. 5: 78.4	Yr. 5: 77.4
Santos et al[16]	2014	Mandard (oesophagus)	Yes	TRG 1 and 2	144	70	56	1.4	8.6	Yr. 5: 81.7	Yr. 5: 79.4
Hav et al[15]	2015	Dworak (rectal)	Yes	TRG 3 and 4	76	28	20			No specific data but no correlation with DFS

Overall rate for total follow-up time. LR: Local recurrence; DR: Distant recurrence; DNE: Data given but not extractable; DFS: Disease-free survival.