Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales

Table 5 Study definitions of poor response according to histopathological tumour regression grade scales

Ref.	Year	TRG scale used (original disease application)	Are the scales reported accurately?	Poor response definition	Total (n)	Poor responders (n)	Average F/up in months	LR (%) 5 yr	DR (%) 5 yr	DFS (%)	OS (%)
Gambacorta et al[21]	2004	Mandard (oesophagus)	Yes	TRG 4	54	10	25
Pucciarelli et al[28]	2004	Mandard (oesophagus)	Yes	TRG 4 and 5	106	52	42
Beddy et al[17]	2008	Wheeler (rectal)	Yes	TRG 2	126	49	37	21		Yr. 5: 71
Giralt et al[22]	2008	Mandard (oesophagus)	No	TRG 4	68	7
Horisberger et al[24]	2008	Japanese Society for Cancer of the Colon and Rectum (rectal)	Yes	TRG 0 and 1a and 1b	59	26
Suárez et al[31]	2008	Mandard (oesophagus)	Yes	TRG 3 and 4 and 5	119	83	33	3.41	14.31	Yr. 2: 83.6
										Yr. 3: 73.8
Bujko et al[18]	2010	Glynne Jones/Bujko (rectal)	Yes	TRG 3	131	29	48	26	47	Yr. 4: 47
Avallone et al[13]	2011	Mandard (oesophagus)	Yes	TRG 4 and 5	63	9	60			Yr. 5: Prob free of recurrence 562
Eich et al[19]	2011	Müller and Junker (lung)	Yes	TRG 1 and 2a	72	28	28			Yr. 2: 76 ± 14.8
Min et al[27]	2011	Rodel (rectal based on Dworak)	Yes	Categorised as poor according to Rodel and based on TRG 0 and 1 on Dworak scale	178	93	43	21	31
Shin et al[30]	2011	Mandard (oesophagus)	Yes	TRG 4 and 5	102	50	40.3			Yr. 3: 72.6
Huebner et al[25]	2012	Dworak (rectal)	Yes	TRG 0+1	237	61
Lim et al[26]	2012	Dworak (rectal)	Yes	TRG 1+2	581	357	61	9.5	27.2	Yr. 5: 63.6	Yr. 5: 71.3
Roy et al[29]	2012	Dworak (rectal)	Yes	TRG 0 and 1	75	42				Yr. 2: 68.9	Yr. 2: 92.6
Roy et al[29]	2012	Mandard (oesophagus)	Yes	TRG 4 and 5	75	24				Yr. 2: 60.3	Yr. 2: 87.3
Vallböhmer et al[32]	2012	Japanese Society for Cancer of the Colon and Rectum (rectal)	Yes	TRG 1	85	23
Vallböhmer et al[32]	2012	Junker Miller (lung)	Yes	TRG 1	85	6					DNE
Vallböhmer et al[32]	2012	Cologne (oesophageal)	Yes	TRG 1 and 2	85	53					DNE
Winkler et al[33]	2012	Dworak (rectal)	No	TRG 1	33	9					DNE
Elezkurtaj et al[20]	2013	Dworak (rectal)	Yes	TRG 0,1 and 2	102	68
Hermanek et al[23]	2013	Rodel (rectal based on Wittekind and Tannapfel (rectal based on Dworak)	Yes	Categorised as poor according to Rodel and based on TRG 0and1 on Wittekind and Tannapfel (a modified Dworak scale)	225	33	92	15.9	27.9	Yr. 5: 63.6	Yr. 5: 75.8
Fokas et al[14]	2014	Dworak (rectal)	Yes	TRG 0+1	386	90	132	Yr. 10: 3.6	Yr. 10: 39.6	Yr. 10: 63%
Santos et al[16]	2014	Dworak (rectal)	Yes	TRG 0,1 and 2	144	85	56	3.5	16.4	Yr. 5: 68.1	Yr. 5: 69.1
Santos et al[16]	2014	Mandard (oesophagus)	Yes	TRG 3 and 4 and 5	144	69	56	4.3	20.3	Yr. 5: 61.7	Yr. 5: 60.7
Hav et al[15]	2015	Dworak (rectal)	Yes	TRG 0,1 and 2	76	48	20			No specific data but no correlation with DFS

¹Overall rate for total follow-up time;

²Probability of being free from recurrence (DFS rate not given). LR: Local recurrence; DR: Distant recurrence.