Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales

Table 1 Characteristics of studies reporting on good or poor response based upon histopathology

Ref.	Year	Chemotherapy protocol with radiotherapy	Radiotherapy protocol (Gy)	Surgical procedures	TME	Time to surgery (wk)	Cancer stage pre neo-adjuvant therapy	Adjuvant therapy
Gambacorta et al[21]	2004	Ralitrexed	50.4	APR/AR/Col-Anal resection/Stoma	Y	6-8	Stage 2 or 3	Y
Pucciarelli et al[28]	2004	Fluorouracil, leucovorin carboplatin, oxaliplatin	45-50.4	APR/AR/Hartmann’s	Y	2-8	T2/3/4, N0/1/2	Y
Beddy et al[17]	2008	Fluorouracil	45-50	APR/AR	Y		T3/4, N1/2
Giralt et al[22]	2008	Tegafir uracil, leucovorin	45 + 9 boost	APR/AR	Y	4-6	T3/4, N0/1/2	Y
Horisberger et al[24]	2008	Capecitabine, irinotecan	50.4	APR/AR/stoma	Y	4-7	T2/3/4, N+
Suárez et al[31]	2008	Fluoropyridine-based	50.4	APR/AR/Hartmann’s	Y	6	Stage 2 or 3	Y
Bujko et al[18]	2010	Fluorouracil, leucovorin	50.4	APR/AR/Hartmann’s	Y	4-6	Stage 2 or 3	Y
Avallone et al[13]	2011	Fluorouracil, levo-folinic acid, ralitrexed, oxaliplatin	45.0	APR/AR/Stoma	Y	< 8	T3/4, N0/1/2	Y
Eich et al[19]	2011	Fluorouracil	50.4	APR/AR/TEMS/Intersphincteric Surgery	Y	4-6	Stage 1,2 or 3	Y
Min et al[27]	2011	Fluorouracil, leucovorin	50.4	APR/AR	Y	6	T3/4, N0/1/2
Shin et al[30]	2011	Fluorouracil	25-50.4	APR/AR/Pan		4-6	T3/4
Huebner et al[25]	2012	Fluorouracil		APR/AR			T1/2/3/4, N0/1/2	Y
Lim et al[26]	2012	Capecitabine, fluorouracil, leucovorin	44-46+4.6 boost	Radical Proctectomy	Y		T3/4, N+	Y
Roy et al[29]	2012	Capecitabine, fluorouracil	45-50		Y	4-6	T1/2/3/4, N0/1/2	Y
Vallböhmer et al[32]	2012	Fluorouracil	50.4	APR/AR	Y		T3/4, N0/1/2
Winkler et al[33]	2012	Capecitabine, oxaliplatin	45-50.4		Y	4-6	Stage 2 or 3	Y
Elezkurtaj et al[20]	2013	Fluorouracil	50.4		Y	4-6
Hermanek et al[23]	2013			APR/AR/Hartmann’s	Y			Y
Fokas et al[14]	2014	Fluorouracil	50.4	APR/AR	Y	4-6	T3/4 or any T and N+	Y
Santos et al[16]	2014	Fluorouracil	50.4	APR/AR	Y	< 8	T2N+ or T3/4	Y
Hav et al[15]	2015	Fluorouracil, cetuximab, oxaliplatin	25-45	AR/Hartmann’s	Y	6-8	T3/4 or any T and N+

APR: Abdominoperineal resection; AR: Anterior resection; Pan: Panproctocolectomy; Col-Anal: Colorectal and anal resection; TME: Total mesorectal excision; Gy: Gray.