Impact of hepatitis C virus core mutations on the response to interferon-based treatment in chronic hepatitis C

Table 3 Predictive factors for sustained virological response, univariate analysis n (%)

Variable	SVR n = 42	No SVR n = 66	P value
Age (yr), median	48.1 (22.1-68.3)	54.7 (22.1-67.3)	< 0.001
Female gender	22 (52.4)	42 (63.6)	0.246
Urban residence (%)	37 (88.1)	41 (62.1)	0.004
Baseline ALT (mg/dL), median	79 (16-890)	75 (17-231)	0.688
Baseline HCV-RNA, median	6.2 (4.15-7.3)	6.2 (4.8; 7.3)	0.167
Mild/moderate fibrosis	18 (75.0)	20 (48.8)	0.107
IL28B type CC (%)	17 (40.5)	2 (3.0)	< 0.001
Absence of core mutations - DW	10 (23.8)	3 (4.5)	0.005
Presence of any core mutation, (%)	32 (76.2)	63 (95.5)	0.005
Viral mutation in core 91 only (%)	15 (60.0)	25 (84.3)	0.024
Viral mutation in core 70 only (%)	2 (16.7)	6 (66.7)	0.032
RVR (%)	13 (31.0)	1 (1.5)	< 0.001
EVR (%)	37 (88.1)	6 (9.1)	< 0.001

HCV: Hepatitis C virus; DW: Double wild-type; SVR: Sustained virological response; EVR: Early virological response; RVR: Rapid virologic response.