Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma

Table 3 Univariate and multivariate Cox proportional hazard regression analysis for clinicopathologic factors overall survival

Factors	Ref.	HR (95%CI)	P value
Univariate analysis
Age1		1.03 (1.00-1.05)	0.023
Sex	Male vs Female	6.29 (1.55-25.4)	0.010
Smoking	Yes vs No	1.36 (0.80-2.33)	0.261
Alcohol	Yes vs No	1.30 (0.80-2.13)	0.286
CEA1		1.07 (0.95-1.20)	0.269
TNM stage	III/IV vs I/II	2.77 (1.97-3.90)	< 0.001
Differentiation	M/D or P/D vs W/D	1.23 (0.82-1.85)	0.308
Neoadj.	Yes vs No	1.70 (1.04-2.78)	0.032
Adj.	Yes vs No	1.73 (1.23-2.45)	0.002
Operation result	R1/R2 vs R0	3.53 (2.25-5.52)	< 0.001
p16	Positive vs Negative	0.49 (0.24-1.01)	0.053
c-Met H-score	≥ 50 vs < 50	1.12 (0.73-1.72)	0.601
Multivariate analysis
Age1		1.03 (1.01-1.06)	0.001
Sex	Male vs Female	4.31 (1.06-17.6)	0.042
TNM stage	III/IV vs I/II	2.52 (1.64-3.87)	< 0.001
Neoadj.	Yes vs No	1.26 (0.73-2.19)	0.405
Adj.	Yes vs No	0.91 (0.58-1.44)	0.685
Operation result	R1/R2 vs R0	2.53 (1.48-4.32)	0.001
p16	Positive vs Negative	0.51 (0.25-1.05)	0.069

¹Treated as continuous variables. CEA: Carcinoembryonic antigen; TNM: Tumor-node-metastasis; W/D: Well differentiated; M/D: Moderately differentiated; P/D: Poorly differentiated; Neoadj.: Neoadjuvant chemotherapy; Adj.: Adjuvant chemotherapy.