Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma

Table 2 Univariate and multivariate logistic regression analysis for clinicopathologic factors affecting programmed death ligand-1 expression

Factors	Ref.	OR (95%CI)	P value
Univariate analysis
Age1		0.98 (0.94-1.02)	0.323
Sex	Male vs Female	1.01 (0.29-3.48)	0.99
Smoking	Yes vs No	1.23 (0.53-2.86)	0.63
Alcohol	Yes vs No	1.07 (0.47-2.42)	0.873
CEA1		0.86 (0.66-1.11)	0.234
TNM stage	III/IV vs I/II	1.59 (0.87-2.89)	0.133
Differentiation	M/D or P/D vs W/D	2.12 (0.98-4.58)	0.058
Neoadj.	Yes vs No	1.37 (0.53-3.53)	0.517
p16	Positive vs Negative	1.56 (0.62-3.92)	0.34
c-Met H-score	≥ 50 vs < 50	2.43 (1.21-4.88)	0.012
Multivariate analysis
Differentiation	M/D or P/D vs W/D	2.01 (0.92-4.40)	0.08
c-Met H-score	≥ 50 vs < 50	2.34 (1.16-4.72)	0.017

¹Treated as continuous variables. OR: Odds ratio; CEA: Carcinoembryonic antigen; TNM: Tumor-node-metastasis; W/D: Well differentiated; M/D: Moderately differentiated; P/D: Poorly differentiated; Neoadj.: Neoadjuvant chemotherapy.