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©The Author(s) 2016.
World J Gastroenterol. Oct 7, 2016; 22(37): 8314-8321
Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8314
Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8314
Table 1 Summary of hepatocellular carcinoma prediction models
| IPM | CU-HCC | GAG-HCC | REACH-B | LSM-HCC | mREACH-B | PAGE-B | |
| Full name | Individual Prediction Model | Chinese University-HCC | Guide with Age, Gender, HBV DNA, Core Promoter Mutations and Cirrhosis-HCC | Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B | Liver Stiffness Measurement-HCC | Modified Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B | |
| Calculation | Risk Index (RI) for HCC = eA, A = -6.2543 + (1.7219 × liver cirrhosis) + (1.3145 × old age over 40 yr) + (1.2631 × chronic HCV infection) + (0.8257 × AFP > 20 ng/mL) + (0.7754 × chronic HBV infection) + (0.7339 × chronic hepatitis) + (0.5840 × heavy alcoholics) + (0.3 × man) + (0.2830 × ALT > 40 IU/L) + (0.221 × unknown alcohol history) | Age (> 50 yr = 3; ≤ 50 = 0) + albumin ( ≤ 35 g/L = 20; > 35 = 0) + bilirubin (> 18 μmol/L = 1.5; ≤ 18 = 0) + HBV DNA (< 4 log copies/mL = 0; 4-6 = 1; > 6 = 4) + cirrhosis (yes = 15; no = 0) | 14 × sex (male = 1; female = 0) + age (in years) + 3 × HBV DNA (log copies/mL) + 33 × cirrhosis presence = 1; absence = 0) | Male sex: 2 points Age: 1 point for every 5 yr from 35 to 65 yr of age (0-6 points) ALT (IU/L): 15-<45 (1 point), ≥ 45 (2 points) Positive HBeAg: 2 points HBV DNA (log copies/mL): 4-< 5 (3 points), 5-< 6 (5 points), ≥ 6 (4 points) | Age (> 50 yr = 10; ≤ 50 = 0) + albumin ( ≤ 35 g/L = 1; > 35 = 0) + HBV DNA (> 200000 IU/mL = 5; ≤ 200000 = 0) + liver stiffness ( ≤ 8.0 kPa = 0; < 8.0-12.0 = 8; > 12.0 = 14) | Male sex: 2 points Age: 1 point for every 5 yr from 35 to 65 yr of age (0-6 points) ALT (IU/L): 15-< 45 (1 point), ≥ 45 (2 points) Positive HBeAg: 2 points Liver stiffness values: < 8.0 kPa (0 point), 8.0-13.0 (2 points), > 13.0 kPa (4 points) | Age; < 30 (-4 points), 30-39 (-2 points), 40-49 (0 point), 50-59 (2 points), 60-69 (4 points), ≥ 70 (6 points) Male sex: 5 points Platelets (mm3): ≥ 200 × 103 (0 point), 100× 103-< 200 × 103 (6 points), < 100 × 103 (11 points) |
- Citation: Lee HW, Ahn SH. Prediction models of hepatocellular carcinoma development in chronic hepatitis B patients. World J Gastroenterol 2016; 22(37): 8314-8321
- URL: https://www.wjgnet.com/1007-9327/full/v22/i37/8314.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i37.8314