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©The Author(s) 2016.
World J Gastroenterol. Oct 7, 2016; 22(37): 8271-8282
Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8271
Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8271
Table 2 Predictive serum biomarkers for hepatitis B virus-associated hepatocellular carcinoma
Marker | Cut-off | Increased risk for HCC | Control group1 | Follow-up time | Ref. | |
Viral | HBeAg | Positive | 4-fold | HBeAg negative HBV patients | 8 yr | [114] |
HBV DNA | > 1 million copies/mL | 11-fold | HBV patients with HBV DNA < 300 copies/mL | 11 yr | [115] | |
HBsAg | > 1000 IU/mL | 3-fold | HBV patients with HBsAg 5-9 IU/mL | 14.7 yr | [117] | |
Host | Gamma-GT Iso-enzyme II | Positive | 86-fold | GGT Iso-enzyme II negative HBV patients | 10 yr | [128] |
Gamma-GT | > 41 U/L | 8-fold | HBV patients with Gamma-GT ≥ 41 U/L | 5.9 yr | [129] | |
AFP | > 5 ng/mL | 8-fold | HBV patients with AFP ≤ 5 ng/mL | 5.9 yr | [129] | |
COMP | Positive | 3-fold | COMP negative HBV and HCV patients | 8 yr | [134] | |
IL-6 | > 7 pg/mL | 3-fold | HBV patients with IL-6 < 7 pg/mL | 7.25 yr | [135] | |
sPD-1 | > 637.6 pg/mL | 2-fold | HBV patients with sPD-1 < 117.3 pg/mL | 20 yr | [138] |
- Citation: Van Hees S, Michielsen P, Vanwolleghem T. Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma. World J Gastroenterol 2016; 22(37): 8271-8282
- URL: https://www.wjgnet.com/1007-9327/full/v22/i37/8271.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i37.8271