Review
Copyright ©The Author(s) 2016.
World J Gastroenterol. Oct 7, 2016; 22(37): 8271-8282
Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8271
Table 1 Diagnostic serum biomarkers for hepatitis B virus-associated hepatocellular carcinoma
MarkerCut-off1SensitivitySpecificityDetection method (most reliable)Ref.
AFP7.7-112.0 ng/mL25%-90%87%-97%ELISA[36,73]
AFP-l33%-20%36%-96%89%-94%Liquid-Phase Binding Assay[46,47,52]
DCP40-150 mAU/mL44%-91%68%-99%Electrochemiluminescence immunoassay[36,53]
Osteopontin9.3-642.5 ng/mL73%-97%55%-100%ELISA[65]
GP7378-150 ng/mL68%-95%9%-97%Immunoblotting, Western Blotting or ELISA2[36,71,72]
GPC-32-300 ng/mL36%-100%40%-100%ELISA[36,78]
SCCA0.12-3.80 ng/mL42%-80%50%-88%ELISA[36,81]
DKK11.01-2.15 ng/mL69%-91%62%-91%ELISA[86-88]
miRNA-21NA84%-90%71%-92%qRT-PCR[83]
miRNA-122NA70%-82%69%-84%qRT-PCR[83]