Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014

Table 5 Subgroup analysis metabolic etiology

			Metabolic (interaction P = 0.300)		Metabolic alone (interaction P = 0.058)
Subgroup	Period	Patients, n	n (%)	OR (95%CI)	n (%)	OR (95%CI)
Age < 50 yr	1998-2000 (Ref.)	132	56 (42)	1	44 (33)	1
	2001-2003	114	54 (47)	1.21 (0.73-2.00)	41 (36)	1.10 (0.65-1.87)
	2004-2006	155	64 (41)	0.93 (0.58-1.49)	52 (34)	0.97 (0.59-1.59)
	2012-2014	111	52 (47)	1.08 (0.64-1.82)	44 (40)	1.16 (0.67-1.99)
Age ≥ 50 yr	1998-2000 (Ref.)	163	80 (49)	1	48 (29)	1
	2001-2003	137	67 (49)	0.98 (0.62-1.55)	37 (27)	0.87 (0.52-1.44)
	2004-2006	181	103 (57)	1.36 (0.89-2.08)	79 (44)	1.81 (1.15-2.83)
	2012-2014	170	81 (48)	0.97 (0.63-1.50)	72 (42)	1.86 (1.18-2.94)

ORs were estimated by a logistic model including an interaction between the variables age and period.