Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas

Table 3 Multivariate Cox regression analysis results of selected parameters

	Hazard ratio	95%CIlower	95%CIupper	P value
CA II epithelium intensity analysis
CA II epithelium intensity	1.19	1.04	1.37	0.0092
Sex (men vs females)	1.20	0.92	1.58	0.1777
Age over 65 yr	1.78	1.35	2.35	P < 0.0001
Side of colon (sin vs dex)	1.17	0.86	1.58	0.3170
CA II epithelium extent analysis, age ≤ 65 yr
CA II epithelium extent	0.88	0.73	1.06	0.1742
Sex (men vs females)	0.99	0.65	1.51	0.9564
Side of colon (sin vs dex)	1.63	0.97	2.74	0.1869
CA II epithelium extent analysis, age > 65 yr
CA II epithelium extent	1.42	1.16	1.73	0.0006
Sex (men vs females)	1.44	1.01	2.05	0.0435
Side of colon (sin vs dex)	0.92	0.63	1.35	0.6764
CA XII epithelium intensity analysis
CA XII epithelium intensity	1.18	1.01	1.38	0.0360
Sex (men vs females)	1.23	0.94	1.60	0.1301
Age over 65 yr	1.67	1.27	2.19	0.0002
Side of colon (sin vs dex)	1.09	0.81	1.47	0.5571

Regression analyses are stratified by Dukes and differentiation status. Separate analyses were done for each carbonic anhydrases (CAs) staining. Due to interaction between age and epithelium extent, the analysis was split in different age groups.