Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

Figure 5 Effects of the high fructose, high cholesterol diet and dietary advanced glycation end products manipulation on fibrosis in the receptor for advanced glycation end products KO animals. A: The absence of receptor for advanced glycation end (RAGE) attenuated the effects of increasing the advanced glycation end products (AGEs) content of the high fructose, high cholesterol (HFHC) diet as evidenced by a reduction in picrosirius red staining to levels observed in animals on the HFHC diet alone; B: There was a commensurate reduction in COL1A gene expression; C: A reduction in hepatic 4-hydroxynonenal content (^aP < 0.05).