Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases

Figure 3 Interplay of AMBRA1, c-MYC and mTOR in colorectal cancer cells. AMBRA1 links autophagy to cell proliferation by facilitating c-MYC demolition. AMBRA1 promotes c-MYC phosphorilation and proteasomal degradation, therefore prevents hyperprolifearion and tumorigenesis. mTORC1 negatively controls the function of AMBRA1, thus finally supporting c-MYC-driven cell proliferation. Arrows represent stimulation or increase; blocked arrows represent inhibition; broken lines represent indirect effects. AMBRA1: Activating molecule in Beclin-1 regulated autophagy; mTORC1: Mammalian target of rapamycin complex 1; PP2A: Protein phosphatase 2A.