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©The Author(s) 2016.
World J Gastroenterol. Sep 21, 2016; 22(35): 8050-8059
Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.8050
Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.8050
Table 1 Characteristics of study cohort patients
Demographics | ||
n | 260 | |
Age | (yr)1 | 53 (44-60) |
Sex | Male/Female n (%) | 157 (60)/103 (40) |
Baseline viral characteristics | ||
Genotype 1a/1b/1x | n (%)/n (%)/n (%) | 76 (29)/115 (44)/3(1) |
Genotype 2/3 | n (%)/n (%) | 8 (3)/44 (17) |
Genotype 4/5/6 | n (%)/n (%) | 11 (4)/1 (0.4)/2 (0.8) |
Baseline viral load | (IU/mL)1 | 1.33 Mio. (414.750-3.4 Mio.) |
Baseline viral load ≥ 800.000 IU/mL | n (%) | 169 (65) |
Baseline viral load ≥ 6 Mio IU/mL | n (%) | 28 (11) |
Special populations | ||
LCi2 | n (%) | 89 (34) |
Low platelets ( ≤ 100/nL) | n (%) | 56 (22) |
Post Liver Transplantation | n (%) | 17 (7) |
Patients ≥ 60 yr | n (%) | 72 (28) |
Patients with MELD score ≥ 10 | n (%) | 25 (10) |
Treatment history | ||
Treatment experienced | n (%) | 144 (55) |
Treatment regimens [thereof liver cirrhosis n (%)] | ||
SOF PR | n (%)/LCi n (%) | 51 (20)/6 (12) |
SOF R | n (%)/LCi n (%) | 10 (4)/4 (40) |
SOF SMV | n (%)/LCi n (%)/R n (%) | 30 (12)/16 (53)/15 (19) |
SOF DCV | n (%)/LCi n (%)/R n (%) | 81 (31)/42 (52)/12 (40) |
SOF LDV | n (%)/LCi n (%)/R n (%) | 73 (28)/17 (23)/16 (22) |
3D | n (%)/LCi n (%)/R n (%) | 15 (6)/4 (27)/6 (40) |
Baseline clinical chemistry | ||
WBC | (/μL)1 | 5935 (4683-7670) |
Hemoglobin | (g/dL)1 | 14.5 (13.1-15.6) |
Platelets | (thousand/μL)1 | 174 (113-228) |
Creatinine | (mg/dL)1 | 0.7 (0.6-0.8) |
Total Bilirubin | (mg/dL)1 | 0.7 (0.5-1.0) |
INR | INR1 | 1 (1-1) |
ALT | IU/l1 | 67 (44-105) |
- Citation: Werner CR, Schwarz JM, Egetemeyr DP, Beck R, Malek NP, Lauer UM, Berg CP. Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12. World J Gastroenterol 2016; 22(35): 8050-8059
- URL: https://www.wjgnet.com/1007-9327/full/v22/i35/8050.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i35.8050