Role of spleen elastography in patients with chronic liver diseases

Table 2 Primary studies assessing the role of spleen elastography in the staging of liver severe fibrosis/cirrhosis

Ref.	Technique	Cut-off	Patients	Sens	Spec	LR+	LR-	PPV	NPV	AUROC
Chen et al[29], 2012 (prospective)	ARFI	3.32	163	80.0	88.4	6.9	0.23	55.5	96.0	0.93 (0.89-0.97)
Fraquelli et al[20], 2013 (prospective)	TE	46.00	110	89.0	78.0	4.5	0.10	54.7	95.0	0.84 (0.76-0.92)
Cabassa et al[30], 2015 (prospective)	ARFI	3.05	51	73.0	84.0	4.5	0.32	91.0	77.0	0.80 (0.68-0.93)
Bota et al[28], 2010 (prospective)	ARFI	2.51	67	85.2	91.7	10.2	0.16	73.3	87.1	0.910
Grgurevic et al[39], 2015 (prospective)	RT-2D SWE	24.00	66	66.7	86.7	5.01	0.38	75.0	81.3	0.821

ARFI: Acoustic radiation force impulse; AUROC: Area under receiver operative curves; LR+: Likelihood ratio positive; LR-: Likelihood ratio negative; RT 2D-SWE: Real-time two-dimensional shear-wave elastography; TE: Transient elastography; PPV: Positive predictive value; NPV: Negative predictive value.