Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients

Figure 5 Effect of different tumor necrosis factor α genotypes on liver pathological parameters (inflammation, steatosis and fibrosis). The effect of high expressing TNFα genotypes (GA + AA) were statistically compared with the low expressing TNFα genotype (GG), and the results showed strong effect of (GA + AA) genotypes on liver inflammation (P = 0.007), steatosis (P = 0.005) and fibrosis (P = 0.032). P≤ 0.05 is considered significant while P≤ 0.01 is highly significant. TNFα: Tumor necrosis factor alpha; HCV: Hepatitis C virus.