Cost effectiveness of routine duodenal biopsies in iron deficiency anemia

Table 2 Base-case values and ranges used in sensitivity analysis in our model

Variable	Base	Low	High	Ref.
Transition probability continuing strict diet given the patient was on strict diet1	0.90	0.60	0.90	[37,38]
Transition probability to normal diet from strict diet	0.20	0.20	0.60	Assumption
Transition probability continuing normal diet given the patient was on normal diet	0.30	0.20	0.60	Assumption
Probability finding celiac due to symptoms	0.20	0.10	0.40	Assumption
Prevalence of celiac in IDA patient	0.05	0.05	0.10	[18,20-23]
Discount rate of costs	0.03	0.00	0.05	Assumption
Specificity of serologic tests	0.99	0.89	0.99	[24-26]
Sensitivity of serologic tests	0.93	0.89	0.96	[24-26]
Utility of CD	0.92	0.90	1.00	[40-43]
Utility of GFD	0.99	0.95	1.00	Assumption
Rate of Overt CD	0.80	0.75	0.90	Assumption
of Weibull distribution	0.2686	0.26	0.29	Assumption
of Weibull distribution	1.1668	1.15	1.18	Assumption
HR mortality of CD patients vs general population	1.39	1.33	1.45	[29-34]

¹Annual transitions probabilities. IDA: Iron deficiency anemia; CD: Celiac disease; GFD: Gluten free diet; HR: Hazard ratio.