Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients

Table 5 Stepwise logistic regression analysis for the effect of tumor necrosis factor α -308 genotypes and alleles on liver disease progression

TNF genotype	Regression coefficient	SE	OR (95%CI)	P value
Activity
GG vs GA + AA	1.329	0.507	3.776 (1.399-10.194)	0.009
G vs A allele	1.171	0.400	3.226 (1.474-7.060)	0.003
Steatosis
GG vs GA + AA	1.502	0.580	4.491 (1.441-14.000)	0.010
G vs A allele	1.099	0.373	3.000 (1.445-6.228)	0.003
Fibrosis
GG vs GA + AA	1.044	0.493	2.841 (1.080-7.472)	0.034
G vs A allele	0.895	0.366	2.446 (1.195-5.008)	0.014

P≤ 0.05 is considered significant while P≤ 0.01 is highly significant. TNF: Tumor necrosis factor.