Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients

Table 3 Tumor necrosis factor α serum level in 120 hepatitis C virus patients

	TNFαserum levels				P value
	GG	GA	AA	GA + AA	GG vs AA
All fibrosis patients (F0-F4, n = 120)	9.1 ± 2.6	12.1 ± 4.9	16.1 ± 4.9	13.1 ± 5.1	0.0001
early fibrosis patients (F0-F1, n = 60)	8.3 ± 2.6	10.1 ± 4.5	16.2 ± 4.02	10.9 ± 4.9	0.010
late fibrosis patients (F2-F4, n = 60)	10.4 ± 2.1	13.8 ± 4.5	16.1 ± 5.6	14.4 ± 4.9	0.002

The TNFα serum level produced by different TNFα -308 genotypes GG, GA and AA were detected in early and late HCV fibrosis patients. The TNFα serum level is represented as mean ± SD and was statistically compared in patients with genotype GG to those with AA genotype. P≤ 0.05 is considered significant, while P≤ 0.01 is highly significant. TNFα: Tumor necrosis factor alpha; HCV: Hepatitis C virus.