Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury

Figure 14 Effect of Haemoxygenase induction and inhibition on CINC. A: The CINC cytokine levels in sham were low (101.32 ± 6.42). RIPC in sham led to relatively high CINC levels (412.18 ± 65.24) as compared to sham (P < 0.05). Hepatic. IR injury produced high serum CINC level in comparison to sham animals in the early phase of hepatic IR (644.08 ± 181.24) (P < 0.05). RIPC reduced CINC-1 levels in the early phase (401.62 ± 78.56) in comparison to IR only. PDTC (HO inducer) reduced CINC-1 levels in serum in hepatic IR (413.36 ± 63.06). HO inhibition in preconditioned animals with Zinc protoporphyrin increased serum CINC levels (521.81 ± 74.9) (P < 0.05); B: The serum CINC levels were high in the late phase of hepatic IR (15306 ± 1222.04). RIPC reduced CINC levels in the late phase of IR (467.46 ± 26.06). HO: Haemoxygenase; IR: Ischemia reperfusion.