Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury

Figure 12 In the late phase of hepatic IR (24 h) there was increased HO expression in both kupffer cells and hepatocytes (parenchymal cells) in preconditioned animals in comparison to IR only. A: Spatiotemporal distribution of HO - There is some HO expression seen in macrophages (kupffer cells) in IR injury in response to oxidative stress. The expression of HO-1 was significantly more in kupffer cells in the RIPC+IR group. ZNPP + RIPC + IR reduced HO-1 expression; B: HO expression in early phase of hepatic IR; C: HO expression in late phase of hepatic IR.