Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury

Figure 11 Hepatocytes showed vacuolation. A: IR - the HE section shows large areas of necrosis and sinusoidal congestion, normal residual hepatocytes noted at bottom of the frame; B: RIPC + IR - The HE section shows sinusoidal congestion, some hepatocyte vacuolation but no significant necrosis; C: Sham - The HE section reveals no significant damage; D: RIPC + Sham - The HE section reveals congested central vein but no other significant change; E: PDTC + IR-diffuse congestion and patchy necrosis; F: ZNPP + RIPC + IR - extensive necrosis seen; G: Very severe injury with abundant ballooning degeneration and necrosis is seen in the IR-24 injury group. Very diffuse and significant neutrophil adhesion is seen in the IR group. Apoptosis is evident in the IR group; H: RIPC + IR-24 group shows less injury with some ballooning and degeneration as well as neutrophilic infiltration. RIPC: Remote ischemic preconditioning; IRI: Ischemia reperfusion injury; HO: Haemoxygenase.