Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy

Table 1 Experimental associating liver partition with portal vein ligation for staged hepatectomy models

Ref.	Year	Species	PVL	PHx in stage I	PHx in stage II	Loss of liver mass	Atrophy of ligated lobe on day 7	Future remnant liver lobe	Fold increase on day 7	Proliferation
Schlegel et al[42]	2014	Mouse	RML	LLL (30%)	Ligated lobes	85% totally (55% PVL + 30% PHx)	NA	LML (15%)	4-fold	Peaked on day 4
			RL
			CL
Yao et al[70]	2014	Rat	LLL	NA	NA	80% PVL	NA	RML (20%)	2.5-fold	Peaked on day 2
			LML
			RL
			CL
Almau Trenard et al[71]	2014	Rat	LLL	NA	NA	80% PVL	Reduction to 35.2%	RML (20%)	2-fold	NA
			LML
			RL
			CL
Dhar et al[54]	2015	Rat	LLL	NA	NA	80% PVL	NA	RML (20%)	2-fold	Peaked on day 2
			LML
			RL
			CL
Wei et al[58]	2015	Rat	LLL	CL (10%)	Ligated lobes	80% totally (70% PVL + 10% PHx)	Reduction to 48.2%	RML (20%)	2.53-fold	Peaked on day 1
			LML
			RL
García-Pérez et al[59]	2015	Rat	RSL	RML (20%)	Ligated lobes	80% totally (60% PVL + 20% PHx)	N/A	LML (22%)	2-fold	Peaked on day 2
			RIL
			LLL
			RML
Shi et al[60]	2015	Rat	RML	LLL (30%)	Ligated lobes	80% totally (50% PVL + 30% PHx)	Reduction to 34.9%	LML (20%)	2.3 fold	Peaked on day 2
			RL
			CL

ALPPS: Associating liver partition with portal vein ligation for staged hepatectomy; CL: Caudate lobe; LLL: Left lateral lobe; LML: Left median lobe; PHx: Partial hepatectomy; PVL: Portal vein ligation; RL: Right lobe; RSL: Right superior; RIL: Right inferior; RML: Right portion of the middle lobes.