Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil: A national survey

Table 4 Distribution of mutations in the gyrA gene in each region

Region	Northern	North-Eastern	Central-Western	South-Eastern	Southern	Total
Codon 87 mutant
No ident1	-	6	1	10	2	19
Gyr87 MUT2	1	4	-	4	2	11
Total	1	10	1	14	4	30
Codon 91 mutant
No ident1	-	2	-	4	2	8
MUT13	-	7	2	9	5	23
MUT24	-	2	-	7	3	12
MUT35	-	1	1	4	3	9
Total		12	3	24	13	52
Multiple mutations in codon 91
MUT1 + MUT3	-	1	1	-	2	4
MUT1 + MUT2	-	-	-	3	1	4
MUT1 + MUT2 + MUT3		-	-	1		1
Total	-	1	1	4	3	9
Codons 87 + 91 mutants	-	2	-	3	2	7
Total mutations	1	22	4	38	17	82

¹Mutant codon not specified;

²Mutation at codon N87K, nucleotide AAA;

³Mutation at codon D91N, nucleotide AAT;

⁴Mutation at codon D91G, nucleotide GGT;

⁵Mutation at codon D91Y, nucleotide TAT.