Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis

doi:10.3748/wjg.v22.i33.7579

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 7, 2016; 22(33): 7579-7586
Published online Sep 7, 2016. doi: 10.3748/wjg.v22.i33.7579

Table 5 Comparison of biochemical indexes between typed drug-induced liver injury and primary biliary cirrhosis patients (median)

	TP (g/L)	ALB (g/L)	AST (U/L)	ALT (U/L)	ALP (U/L)	GGT (U/L)	TBIL (μmol/L)	DBIL (μmol/L)	IBIL (μmol/L)
Hepatocellular type DILI (n = 90)	66.8 ± 8.0^a	39.2 ± 6.2	442.5 (174.3-941.5)^a	574.0 (205.6-1263.3)^a^c^e	145.5 (86.3-217.5)^a^c^e	179.0 (87.0-366.1)^a	74.30 (32.4-160.7)	46.2 (17.8-96.6)	16.2 (11.4-19.5)
Cholestatic type DILI (n = 20)	63.7 ± 7.2^a	39.1 ± 5.8	135.0 (82.6-185.8)	154.0 (49.2-253.8)	320.6 (196.6-454.2)	208.50 (110.5-426.8)	126.90 (55.3-266.7)	99.0 (38.8-214.3)	26.2 (13.3-35.2)
Mixed type DILI (n = 14)	70.8 ± 8.6	37.6 ± 4.4	654.1 (317.2-1389.1)^a^c	844.0 (551.8-1945.8)^a^c	328.75 (258.4-477.2)	260.50 (142.8-418.5)	111.10 (41.3-234.9)^a	95.2 (56.7-266.8)^a	21.9 (14.6-33.2)^a
PBC (n = 116)	74.9 ± 9.4	37.6 ± 6.0	113.5 (74.8-190.5)	113.0(69.0-193.3)	264.0 (166.3-443.3)	311.5 (148.0-660.3)	78.6 (25.2-189.0)	16.3 (5.8-60.6)	10.9 (7.4-21.6)

^aP < 0.05 vs the PBC group;

^cP < 0.05 vs the cholestatic type DILI group;

^eP < 0.05 vs the mixed type DILI group. DILI: Drug-induced liver injury; PBC: Primary biliary cirrhosis; TP: Total protein; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; GGT: Gamma glutamyl transferase; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; ALP: Alkaline phosphatase.

Citation: Yang J, Yu YL, Jin Y, Zhang Y, Zheng CQ. Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis. World J Gastroenterol 2016; 22(33): 7579-7586
URL: https://www.wjgnet.com/1007-9327/full/v22/i33/7579.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i33.7579