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©The Author(s) 2016.
World J Gastroenterol. Sep 7, 2016; 22(33): 7389-7401
Published online Sep 7, 2016. doi: 10.3748/wjg.v22.i33.7389
Published online Sep 7, 2016. doi: 10.3748/wjg.v22.i33.7389
Table 2 Summary of dietary regulation of microRNAs, potentially relevant to colorectal cancer
MicroRNA | Study population | Diet or nutrient | Analysis method | Findings | Specimen type | Ref. |
miR-16 miR-21 miR-34a miR-92a miR-106a miR-146 miR-222 | Italian-based 8 vegans 8 vegetarians 8 omnivores | Meat, processed meat, fish, cheese | Food frequency and lifestyle questionnaire | miR-92a was significantly decreased by meat and dairy products, and associated with low body mass index. Weaker associations found between miR-21 levels and vegetable intake | Plasma and stool | Tarallo et al[38] |
Let-7d miR-15b miR-107 miR-191 miR-324-5 | Sprague-Dawley rats, treated with saline or the carcinogen, azoxymethane | Corn oil vs fish oil in the diet | Effects of diets on the expression of 368 miRNAs in the colonic mucosa | The five identified miRNAs were the most strongly affected by diet X carcinogen actions. The fish fed animals showed the smallest number of differentially expressed miRNAs - interpreted as due to a reduction in inflammation | Colonic mucosa | Davidson et al[39] |
miR-1903 miR-467c miR-368 miR-927c | Female athymic nude mice, injected with HT-29 colon cancer cells | Corn oil vs ground walnuts in the diet | Effects of the diets on the expression of four microRNAs in the colon tumours | The first three of these microRNAs were down-regulated and the latter up-regulated in expression. These data were related to significant increases in α-linolenic, eicosapentaenoic, docosahexaenoic and total omega-3 acids, and a decrease in arachidonic acid in the walnut fed mice | Colorectal tumour tissue | Tsoukas et al[40] |
miR-155 | Young subjects (22 + 2 yr), smokers and non-smokers | High dose vitamin C daily for 8 wk | Expression level of miR-155 in HDL3 | miR-155 reduced in HDL fraction by 49% in non-smokers and 75% in smokers after 8 wk supplementation. This effect was related to a reduction in reactive oxygen species | Serum lipoprotein levels | Kim et al[43] |
miR-98 miR-92a miR-30e miR-140-5p miR-138 | 7 different prostate cell models including malignant and non-malignant | 30 min treatment with 1a,25(OH)2D3 | MiRNA microarray analyses | 111 miRNAs showed changed expression levels, but only 5 were seen affected in more than one cell line and only 3 were changed in the same direction | Total mRNA and miRNA from each cell line. | Singh et al[44] |
miR-22 miR-29ab miR-134 miR-1207-5p miR-371-5p miR-17 miR-20a | LNCaP human prostate cancer cells | 48 h treatment with 100 nmol/L 1,25(OH)2D3 compared with non-treated control, cells | Agilent human microRNA v3 microarrays to measure microRNA expression | Four hundred and twenty genes were up-regulated and 413 genes down-regulated in the 1,25(OH)2D3-treated cells. The most strongly affected are those identified in column 1 (the last two of these miRNAs is downregulated) | Integrative network-based analysis using a publicly available data set | Kutmon et al[45] |
miR-155 | RAW264.7 macrophage cells stimulated with lipopolysaccharide (LPS) | 24 h in the presence of EtOH or 20 nmol/L 1,25(OH)2D3 | miRNA profiling by microarrays | Several miRNAs were induced by LPS and suppressed by 1,25(OH)2D3, of which miR-155 was on the top of the list, suppressing about 50% of the LPS induction | Total mRNA and miRNA from each cell line | Li et al[46] |
miR-22 | SW480-ADH and HCT116 colon cancer cells | 10-7 mol/L 1,25(OH)2D3 for 24, 48 or 96 h | miRNA profiling by microarrays | Although there were 12 microRNAs that showed differential expression with and without vitamin D, miR-22 showed the most consistent differences | Total miRNA from each cell line | Alvarez-Díaz et al[48] |
Let-7f Let-7a miR-151-5p miR-22 miR-221 miR-28-5p miR-552-3p miR-766 miR-99b | Males, generally in good health, with no diabetes or other concomitant diseases | High dose vitamin D3 (20000-40000 IU per week) | Quantitative real-time PCR | In 10 pilot subjects, 136 miRNAs were changed in expression in one or more plasma samples drawn at baseline and after 12 mo of vitamin D supplementation. The twelve miRNAs that showed the greatest change in expression in the pilots were further measured in RNA from baseline and 12 mo plasma samples in 40 subjects given vitamin D and 37 subjects given placebo | Plasma | Jorde et al[47] |
miR-122a miR-125b | Fischer 344 rats | 0, 12 or 24 mg/kg | Quantitative real-time PCR | Vitamin E sufficiency resulted in increased concentrations of miRNA-122a and miRNA-125b | Liver tissue | Gaedicke et al[49] |
miR-625 miR-492 miR-373 miR-22, miR-532-5p miR-106b miR-30b miR-185 miR-203 miR1308 miR-28-5p miR-10b | CaCO2 human colon cancer cells | Selenium-deficient or sufficient medium | Microarray validated with quantitative real-time PCR | Selenium deficiency resulted in altered expression of 12 genes | Total miRNA from combined cells of each treatment | Maciel-Dominguez et al[50] |
miR-21 | U251 human glioblastoma cells | 10, 50 or 100 umol/L Resveratrol for 72 h | Quantitative real-time PCR | Resveratrol inhibited miR-21 expression which in turn suppressed NF-κB activity. However, over-expression of miR-21 could reverse the effect of resveratrol on NF-κB activity and apoptosis | Cell extracts | Li et al[54] |
miR-21 | Estrogen-dependent MCF-7 and estrogen receptor-negative p53 mutant MDA-MB-468 human breast cancer cells | 0, 30 or 60 umol/L | Quantitative real-time PCR | Cells were studied either in tissue culture or as a xenograft in BALB/C female athymic mice miR-21 was up-regulated in DIM-treated MCF-7 cells, but not in the ER negative, p53 mutant MDA-MB-468 cells | Cell extracts | Jin[55] |
miR-30b miR-1224-3p miR-197 miR-523-3 | HepG2 human hepatocarcinoma cells | 3-3’-Diindoyl-methane for 24-96 h 50 mg/L of epigallocatechin gallate (EGCG), 100 mg/L of grape seed extract (GSPE) or 100 mg/L of cocoa proanthocyanidin extract (CPE) | Microarray analysis validated by quantitative real-time PCR | MiR-30b was downregulated by all three treatments, while treatment with GSPE or CPE upregulated miR-1224-3p, miR-197 and miR-532-3p | Cell extracts | Arola-Arnal et al[57] |
miR-210 (plus 13 other miRNAs upregulated and 7 down-regulated) | Tobacco carcinogen-induced lung cancer in A/J mice | Purified mouse chow containing 0.4% EGCG | Microarray analysis validated by quantitative real-time PCR | MiR-210 had been previously found upregulated by EGCG in in vitro experiments, but this ranked behind the 13 most strongly upregulated miRNAs (miR-2137, miR-449a, miR-144, miR-486, miR-3107, miR-193, miR-5130, miR-2861, miR-511-3p, miR-763, miR-3473, miR-211, miR-210) or seven most down regulated in this in vivo study | Tumour tissue, all tumours from a single mouse combined to a single sample | Zhou et al[58] |
- Citation: Lee K, Ferguson LR. MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer. World J Gastroenterol 2016; 22(33): 7389-7401
- URL: https://www.wjgnet.com/1007-9327/full/v22/i33/7389.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i33.7389