Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function

Table 1 Cohort studies (5 reports) and randomized controlled trial (3 reports) were available

Ref.	Group	Patient number	Therapy for HCC	Male/Female	Age (yr)	Child-Pugh A/B/C	Maximum tumor size (mm)	Study design
Togo et al[41]	BCAA	21	Surgery	17/4	66.5 ± 4.5	15/7/0	ND	RCT
2005	control	22		17/5	64.3 ± 9.1	17/5/0	ND
Ichikawa et al[42]	BCAA	26	Surgery	18/8	64.7 ± 9.8	21/5/0	ND	RCT
2012	control	30		20/10	64.5 ± 11.4	25/5/0	ND
Nishikawa et al[43]	BCAA	115	RFA	64/51	69.3 ± 9.4	83/30/2	19.5 ± 6.0	cohort
2013	control	141		85/58	70.9 ± 7.8	88/52/1	19.6 ± 6.6
Yoshiji et al[44]	BCAA	51	RFA	32/19	63.6 ± 15.3	41/10/0	ND	RCT
2013	control	42		25/17	62.2 ± 14.8	33/9/0	ND
Saito et al[45]	BCAA	13	RFA	8/5	73.4 ± 2.2	83/30/2	ND	cohort
2014	control	27		16/11	70.0 ± 1.9	88/52/1	ND
Nishikawa et al[46]	BCAA	40	TACE	27/13	69.9 ± 8.8	6.4 ± 0.4	33.4 ± 16.7	cohort
2012	control	59		32/27	73.2 ± 10.1	5.4 ± 0.1	35.9 ± 14.7
						(score)
Takeda et al[47]	BCAA	34	Sorafenib	27/7	72 (55-88)	16/18/0	ND	cohort
2014	control	44		37/7	68 (46-89)	30/14/0	ND
Imanaka et al[48]	BCAA	55	Sorafenib	45/10	72.2 ± 7.8/73.1 ± 6.4	37/18/0	ND	cohort
2015	control	201		167/34	72.4 ± 8.8/67.2 ± 13.0	179/22/0	ND
					(Child-Pugh A/B)

BCAA: Late evening snack using branched-chain amino acid; RFA: Radiofrequency ablation, TACE: Trans-catheter arterial chemoembolization, ND: Not done; RCT: Randomized control trial.