Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity

Figure 5 Comparative effect of carbamazepine, gabapentin and pregabalin on visceral hypersensitivity in non-inflammatory and inflammation-associated colonic hypersensitivity mouse models. The area under the curve (AUC) (A, C and E) between 80 μL and 100 μL for neonatal maternal separation (NMS) model and (B, D and F) between 60 μL and 80 μL for Dextran Sulfate Sodium (DSS) model has been calculated for both doses of (A and B) carbamazepine (CBZ), (C and D) gabapentin (GBP) and (E and F) pregabalin (PGB). ^aP < 0.05; ^bP < 0.01, ^eP < 0.001, ANOVA 2 Way (Treatment; Dose) followed by Bonferroni post-hoc test for multiple comparisons for each treatment in one CHS model. CHS: Colonic hypersensitivity; DSS: Dextran sulfate sodium.