Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value

Table 3 Association of CHRN expression with characteristics of healthy individuals

Variable	CHRNA3		CHRNA5		CHRNA7		CHRNB4
	Expression,	P value	Expression,	P value	Expression,	P value	Expression,	P value
	median (min-max)		median (min-max)		median (min-max)		median (min-max)
Esophageal thirds
Upper	1.563 × 10-5	0.769	8.431 × 10-5	0.945	1.023 × 10-5	0.789	9.027 × 10-6	0.153
	(2.735 × 10-6 - 7.183 × 10-5)		(1.277 × 10-5 - 2.157 × 10-3)		(1.033 × 10-6 - 5.616 × 10-5)		(2.534 × 10-6 - 2.828 × 10-5)
Middle	1.783 × 10-5		8.476 × 10-5		1.346 × 10-5		1.077 × 10-5
	(1.512 × 10-6 - 1.196 × 10-4)		(1.286 × 10-5 - 2.388 × 10-3)		(2.588 × 10-6 - 6.319 × 10-5)		(3.913 × 10-6 - 3.259 × 10-5)
Lower	1.721 × 10-5		8.906 × 10-5		1.263 × 10-5		1.166 × 10-5
	(2.914 × 10-6 - 6.796 × 10-5)		(1.442 × 10-5 - 1.990 × 10-3)		(1.678 × 10-6 - 5.636 × 10-5)		(3.621 × 10-6 - 4.453 × 10-5)
Age, yr	58		56.5		57		57
> median	2.226 × 10-5	0.422	4.982 × 10-5	0.097	1.189 × 10-5	0.272	1.060 × 10-5	0.778
	(1.512 × 10-6 - 1.019 × 10-4)		(1.286 × 10-5 - 2.388 × 10-3)		(2.588 × 10-6 - 4.391 × 10-5)		(3.913 × 10-6 - 3.192 × 10-5)
≤ median	1.274 × 10-5		9.054 × 10-5		1.449 × 10-5		1.094 × 10-5
	(3.977 × 10-6 - 1.196 × 10-4)		(2.657 × 10-5 - 4.635 × 10-4)		(2.931 × 10-6 - 6.319 × 10-5)		(5.010 × 10-6 - 3.259 × 10-5)
Sex
Male	1.344 × 10-5	0.253	1.104 × 10-4	0.243	1.316 × 10-5	0.807	1.772 × 10-5	0.372
	(3.977 × 10-6 - 5.947 × 10-5)		(2.657 × 10-5 - 3.351 × 10-4)		(2.931 × 10-6 - 4.060 × 10-5)		(5.559 × 10-6 - 2.917 × 10-5)
Female	1.812 × 10-5		7.842 × 10-5		1.375 × 10-5		1.034 × 10-5
	(1.512 × 10-6 - 1.196 × 10-4)		(1.286 × 10-5 - 2.388 × 10-3)		(2.588 × 10-6 - 6.319 × 10-5)		(3.913 × 10-6 - 3.259 × 10-5)
Smoking
Never	1.665 × 10-5	0.400	8.531 × 10-5	0.961	1.210 × 10-5	0.582	1.077 × 10-5	0.599
	(1.512 × 10-6 - 1.019 × 10-4)		(2.051 × 10-5 - 2.388 × 10-3)		(2.588 × 10-6 - 6.319 × 10-5)		(3.913 × 10-6 - 3.192 × 10-5)
Ever	1.948 × 10-5		8.405 × 10-5		1.375 × 10-5		1.078 × 10-5
	(5.157 × 10-6 - 1.196 × 10-4)		(1.286 × 10-5 - 3.351 × 10-4)		(2.931 × 10-6 - 4.256 × 10-5)		(5.010 × 10-6 - 3.259 × 10-5)
Alcohol consumption
Never	2.386 × 10-5	0.163	5.955 × 10-5	0.131	1.046 × 10-5	0.412	1.094 × 10-5	0.521
	(1.512 × 10-6 - 1.196 × 10-4)		(2.051 × 10-5 - 3.525 × 10-4)		(2.588 × 10-6 - 4.256 × 10-5)		(3.913 × 10-6 - 3.259 × 10-5)
Ever	1.274 × 10-5		1.018 × 10-4		1.375 × 10-5		1.007 × 10-5
	(3.977 × 10-6 - 8.783 × 10-5)		(1.286 × 10-5 - 2.388 × 10-3)		(2.931 × 10-6 - 6.319 × 10-5)		(5.010 × 10-6 - 2.917 × 10-5)

Statistical analyses were performed using the Mann-Whitney or Kruskal Wallis test and Dunn's post-test as appropriate; no significant differences were observed.