Development of a human rotavirus induced diarrhea model in Chinese mini-pigs

Table 2 Inoculated mini-pigs with human rotavirus at different points in maturity

Age (d)	Number	Inoculum	Diarrhea1			Viral antigen shedding2
			Percentage (%)	Average (days happened)	Persistent (d)	Percentage (%)	Average (d)	Persistent (d)
3-5	3	G1 HRV	100 (3/3)	1	3-5	100 (3/3)	1	5-7
	3	G3 HRV	100 (3/3)	1	3-6	100 (3/3)	1	5-7
	2	PBS	0	0	0	0	0	0
30-35	3	G1 HRV	100 (3/3)	3	3-5	100 (3/3)	1	4-7
	2	PBS	0	0	0	0	0	0
56-60	3	G1 HRV	0	0	0	0	2	2-3
	2	PBS	0	0	0	0	0	0

¹Diarrhea present if daily fecal consistency score ≥ 2, mean cumulative fecal score = ∑ (Daily fecal scores from 1-7 DPI)/n;

²Determined by FFA assay. HRV: Human rotavirus; DPI: Days post infection.