Current understanding concerning intestinal stem cells

doi:10.3748/wjg.v22.i31.7099

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Aug 21, 2016; 22(31): 7099-7110
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7099

Table 3 Characteristics of crypt basement column cells stem cells and reserve intestinal stem cells

ISC type	Main location	Cell-cycle status under intact conditions	Differentiating capability	Foreign stimuli-induced response	Leading pathway	Typical marker genes
CBC stem cell	Crypt basement	Active	Yes	Apoptosis	Wnt/β-catenin	Lgr5
Reserve ISC	4+ position	Slow	Yes	Proliferation	Unknown but independent of Wnt/β-catenin	Bmi1, HopX, Lrig1, mTERT

CBC: Crypt basement column cells; ISC: Intestinal stem cell.

Citation: Cui S, Chang PY. Current understanding concerning intestinal stem cells. World J Gastroenterol 2016; 22(31): 7099-7110
URL: https://www.wjgnet.com/1007-9327/full/v22/i31/7099.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i31.7099