Current understanding concerning intestinal stem cells

doi:10.3748/wjg.v22.i31.7099

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Aug 21, 2016; 22(31): 7099-7110
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7099

Table 1 Bioactive proteins from niche cells maintain the proliferative status in intestinal stem cells

Niche cell	Bioactive protein	Receptor	Target pathway	ISC proliferation	ISC differentiation
Paneth cell	Wnt 3	LRP5/6 and Frizzled	Wnt/β-catenin	↑	/
Paneth cell	Dll1/4	Notch 1/2	Notch	↑	↓
Paneth cell	EGF	EGFR	Ras/Raf/Mek/Erk/MAPK	↑	/
Myofibroblast	R-spondin1	Lgr4/5	Wnt/β-catenin	↑	/
Myofibroblast	Noggin	BMP4	BMP/Smad	/	↓

ISCs: Intestinal stem cells. ↑: Increase; ↓: Decrease; /: No alterations.

Citation: Cui S, Chang PY. Current understanding concerning intestinal stem cells. World J Gastroenterol 2016; 22(31): 7099-7110
URL: https://www.wjgnet.com/1007-9327/full/v22/i31/7099.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i31.7099