Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer

Table 1 Therapeutic approach in reprogramming pancreatic ductal adenocarcinoma

Therapeutic approach	Product	Mechanism	Model studied	Ref.
Chemical	PD325901	Inhibits MEK1/2 in MAPK signaling	Block ADM in in vitro experiment	[16]
			Reprogram pancreatitis- induced PanIN back to acinar cells in in vivo experiment
	Exendin-4	May inhibit ERK1/2 in MAPK signaling	Reprogram PANC-1 cells back to acinar cells and endocrine cells	[82]
	RA	Detailed study is needed	Reprogram HPAF cells to endocrine cells	[107]
Genetic	DKK3 knockdown	Detailed study is needed	Reprogram PANC-1 cells back to acinar cells and endocrine cells	[82]
	E47 overexpression	Functions as a sponge of ID3 to remove the inhibition of acinar transcription factors	Reprogram PDAC cell lines back to acinar cells using both in vitro and in vivo model systems	[100]