Hepatitis E: Discovery, global impact, control and cure

Table 2 Diagnosis of hepatitis E virus infection

Test	Method	Uses	Comments
IgM anti-HEV	ELISA	Acute infection	Assays vary in performance, issue of genotype applicability, poor performance in immune disorders, cross-reactive with other viral infections
	ICT (POCT)
IgG anti-HEV	ELISA	Seroprevalence	Assays vary in performance
	ICT (POCT)	Acute infection
		Natural protection
		Vaccine efficacy
HEV RNA	NAT	Acute infection	Viremia short-lasting, in-house assays vary in performance, advantage immune disorders
		Confirm chronicity
		Anti-viral response
		Donor screening
HEV antigen	EIA	Acute infection	81% concordance with HEV RNA

Adopted from Khuroo et al[143], 2016. HEV: Hepatitis E virus; ICT: Immunochromatographic test; POCT: Point of care test; NAT: Nucleic acid test; EIA: Enzyme immunoassay.