Roles of hepatocyte nuclear factors in hepatitis B virus infection

Table 1 Hepatocyte nuclear factors and other transcription factors involved in hepatitis B virus transcription

Factor	Binding site	Effect on viral enhancers/promoters	Ref.
HNF1α	PreS1	Activation	[60]
	Enh II	Activation (interaction with hB1F)	[61]
	Enh II	Suppression (mutant HBV core promoter)	[50]
	Enh II	Activation	[62]
	Enh II	Activation (mutant HBV core promoter)	[49]
HNF3β	Enh I	Activation (interaction with STAT3)	[48]
	Enh I	Suppression (HepG2)/ Activation (SK-Hep1)	[68]
	Enh II	Suppression	[67]
	Enh II	Activation	[66]
HNF4α	EnhII/PreS1	Activation	[73]
	Enh II	Activation	[130]
HNF6	PreS2	Suppression	[78]
C/EBP	Enh I	Suppression	[83]
	Enh II	Activation	[81]
	Enh II	Activation	[46]
	Enh II	Activation	[80]
FXR/RXR	Enh II	Activation	[99]
HLF	Enh II	Activation	[6]
NF1	PreS2	Activation	[101]
	Enh I	Suppression	[102]
SP1	Enh II	Activation	[104,105]
	PreS1	Activation	[106]
	PreS2	Activation	[107]

HBV: Hepatitis B virus.