Chinese expert consensus on cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancies

Table 3 International studies on gastric peritoneal carcinomatosis treatment by cytoreductive surgery + hyperthermic intraperitoneal chemotherapy

Ref.	Patients	Staging criteria	CCR0 n (%)	HIPEC	Morbidity n (%)	Mortality n (%)	Median follow-up (mo)	Median survival (mo)	Overall survival in years
									1	2	5
Yonemura et al[42]	107	Japanese General Rules for Gastric Cancer Study	47 (43.9)	Open technique, MMC 30 mg, DDP 300 mg, Etoposide 150 mg, 8 L of normal saline, 42-43 °C, 60 min	23 (15.9)	3 (2.8)	46	11.5	35.5%	13.1%	6.7%
								CCR 0: 19.2
								CCR 1-3: 7.8
Yonemura et al[50]	83	Japanese General Rules for Gastric Cancer Study	28 (33.7)	Open technique, MMC 30 mg, DDP 300 mg, Etoposide 150 mg, 8 L of normal saline, 42-43 °C, 60 min	-	-	46	CCR 0: 13.9	43.0%	-	11.0%
								CCR 1-3: 6.8
Yonemura et al[43]	48	Japanese General Rules for Gastric Cancer Study	-	Open technique, MMC 30 mg, DDP 300 mg, 8 L of normal saline, 42-43 °C, 60 min	9 (19.0)	2 (4.0)	-	-	-	-	61.0%
Scaringi et al[44]	26	Gilly's Classification	8 (30.8)	Close technique, MMC 120 mg, DDP 200 mg, 6 L of normal saline, 42-43 °C, 90-120 min	10 (38.5)	1 (3.8)	-	6.6	-	-	-
								CCR 0: 15
								CCR 1-3: 3.9
Fujimoto et al[45]	15	-	-	Close technique, MMC 30-50 mg, 44.7-48.7 °C, 120 min	2 (13.3)	0	-	7.2 ± 4.6	-	-	-
Fujimoto et al[6]	71	TNM Classification	71 (100.0)	Close technique, MMC 10 mg/mL, 44.5-45 °C, 120 min	2 (2.8)	0	7	-	88.0%	76.0%	2.0%
Hall et al[46]	34	-	7 (21.0)	Close technique, MMC 10 mg/mL, 40 °C, 120 min	12 (35.0)	0	-	8	27.0%	23.0%	6.0%
Fujimura et al[47]	31	Japanese General Rules for Gastric Cancer Study	2 (16.0)	Open technique, MMC 20 mg/m2, DDP 200 mg/m2, 6 L of normal saline, 42-52 °C, 90-120 min	6 (19.4)	0	-	9	33.3%	8.3%	0.0%
Hamazoe et al[48]	42	-	40 (95.0)	Close technique, MMC 10 μg/mL, inflow temperature 40-45 °C, outflow temperature 40-42 °C, 60 min	2 (4.8),	0	> 6	77	90.0%	80.0%	64.3%
Kim et al[49]	52	TNM Classification	-	Close technique, MMC 10 μg/mL, inflow temperature 44 °C, 20 min	19 (36.5)	0	38	36	-	-	32.7%
Yang et al[7]	68	Sugarbaker’s Classification	20 (58.5)	Open technique, MMC 30 mg, DDP 120 mg, 42 °C, 120 min	5 (14.7)	0	32	PCI ≤ 20 13.5 PCI > 20 10.2
Chen et al[40]	500	-	-	Open technique, Chlorhexidine diacetate hydrate 0.6 g, 4 L of distilled water, 43 °C, 4 min	-	-	-	-	88.7%	66.2%	63.6%
Zhu et al[41]	52	-	-	Open technique, DDP 50 mg/L, MMC 5 mg/L, 43 °C, 60 min	-	-	72	-	76.9%	69.2%	55.2%