Mechanisms of drug resistance in colon cancer and its therapeutic strategies

doi:10.3748/wjg.v22.i30.6876

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2016; 22(30): 6876-6889
Published online Aug 14, 2016. doi: 10.3748/wjg.v22.i30.6876

Table 2 Potential agents to overcome resistance of cancer cells to apoptosis (non-exhaustive list)

Restoration of apoptotic signals		Alternative cell death		Ref.
BH3 mimetics	EGFR inhibitors	Autophagy inducers	Agents with p53-independent toxicity	Ref.
ABT-199 (venetoclax), ABT-263 (navitoclax), ABT-737, apogossypol, apogossypolone, gossypol, maritoclax, obatoclax, sabutoclax	Afatinib, cetuximab, dacomitinib, erlotinib, gefitinib, lapatinib, matuzumab, neratinib, nimotuzumab, panitumumab, zalutumumab	Clonidine, cryptotanshinone, curcumin, dihydrotanshinone, evodiamine, genistein, helenalin, monascuspiloin, oridonin, paclitaxel, quercetin, rapamycin, resveratrol, sodium valproate, verapamil	Betulinic acid, crocetin, cryptotanshinone, dihydrotanshinone, epigallocatechic-3-gallate, genistein, a-iso-cubebene, resveratrol, triptolide, thymoquinone, ursolic acid	[91,112-115,117,120,121,124,127-129,147-156]

EGFR: Epidermal growth factor receptor.

Citation: Hu T, Li Z, Gao CY, Cho CH. Mechanisms of drug resistance in colon cancer and its therapeutic strategies. World J Gastroenterol 2016; 22(30): 6876-6889
URL: https://www.wjgnet.com/1007-9327/full/v22/i30/6876.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i30.6876