Radiotherapy as valid modality for hepatocellular carcinoma with portal vein tumor thrombosis

Table 3 Prospective and retrospective studies applying radiotherapy with or without transcatheter arterial chemo-embolization in hepatocellular carcinoma with portal vein tumor thrombosis

Ref.	Year	Design	Treatment	No.	OR	Median survival, mo		P value
						OR (+)	OR (-)
Tazawa et al[90]	2001	Retrospective	TACE + RT	24	50.0%	9.7	3.8	< 0.001
Yamada et al[91]	2003	Prospective	TACE + RT	19	57.9%	15.4	4.6	0.16
Kim et al[87]	2005	Retrospective	RT	59	45.8%	10.7	5.3	0.05
Nakazawa et al[89]	2007	Retrospective	RT	32	48.0%	13.8	7.0	0.01
Zeng et al[94]	2008	Retrospective	RT	136	57.6%	19.5 (CR)	7.2 (SD)	< 0.001
						10.2 (PR)	3.5 (PD)
Yu et al[93]	2011	Retrospective	RT ± TACE	281	53.8%	22.0	5.0	< 0.001
Yoon et al[92]	2012	Retrospective	TACE + RT	412	39.6%	19.4	7.0	< 0.001
Kim et al[88]	2014	Retrospective	TACE + RT	59	51.0%	NR	7.0	< 0.001

CR: Complete response; NR: Not reported; OR: Objective response; PD: Progressive disease; PR: Partial response; SD: Stable disease.