Changing strategies for target therapy in gastric cancer

Figure 3 Vascular endothelial growth factor receptor and signal transduction. Binding of ligands to receptors leads to phosphorylation of the receptors by activation of receptor-kinase activity, which leads to subsequent signal transduction. VEGF: Vascular endothelial growth factor; PLC-γ: Phospholipase C-γ; PKC: Protein kinase C; MEK: Protein kinase kinase; MAPK: Mitogen-activated protein kinase; PI3K: Phosphatidylinositol 3-kinase.