Changing strategies for target therapy in gastric cancer

Figure 2 Signal transduction cascade through activation of ERBB receptors and schematic diagram of molecular targeting agents where they work. EGFR: Epidermal growth factor receptor; HER: Human EGFR; PLC-γ: Phospholipase C-γ; PKC: Protein kinase C; MEK: Protein kinase kinase; MAPK: Mitogen-activated protein kinase; mTOR: Mammalian target of rapamycin; PI3K: Phosphatidylinositol 3-kinase.